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Journal Articles

Correction: Transcription of HIV-1 at sites of intact latent provirus integration

Ana Rafaela Teixeira, Cintia Bittar, Gabriela S. Silva Santos, Thiago Y. Oliveira, Amy S. Huang, Noemi Linden, Isabella A.T.M. Ferreira, Tetyana Murdza, Frauke Muecksch, R. Brad Jones, Marina Caskey, Mila Jankovic, Michel C. Nussenzweig
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e2024039105162025c.
https://doi.org/10.1084/jem.2024039105162025c
Published: 23 May 2025
View articletitled, Correction: Transcription of HIV-1 at sites of intact latent provirus integration
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Journal Articles

Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation

Chae Won Kim, Hyun-Jin Kim, In Kang, Keun Bon Ku, Yumin Kim, Jang Hyun Park, Juhee Lim, Byeong Hoon Kang, Won Hyung Park, Jeongwoo La, Sungwoo Chang, Inju Hwang, Minji Kim, Stephen Ahn, Heung Kyu Lee
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241135.
https://doi.org/10.1084/jem.20241135
Published: 22 May 2025
View articletitled, Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation
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Includes: Supplementary data
Journal Articles

A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo

Fanghui Zhang, Javier Celis-Gutierrez, Lichen Zhang, Valentin Mellado, Léna Gelard, Sophie Panigot, Daiki Mori, Liaoxun Lu, Guillaume Voisinne, Carine Vilarnau Wolek, Marielle Mello, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Frédéric Fiore, Romain Roncagalli, Yinming Liang, Marie Malissen, Bernard Malissen
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20250339.
https://doi.org/10.1084/jem.20250339
Published: 22 May 2025
View articletitled, A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo
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Includes: Supplementary data
Journal Articles

A multimorphic variant in ThPOK causes an inborn error of immunity with T cell defects and fibrosis

Maryam Vaseghi-Shanjani, Mehul Sharma, Pariya Yousefi, Simran Samra, Kaitlin U. Laverty, Arttu Jolma, Rozita Razavi, Ally H.W. Yang, Mihai Albu, Liam Golding, Anna F. Lee, Ryan Tan, Phillip A. Richmond, Marita Bosticardo, Jonathan H. Rayment, Connie L. Yang, Kyla J. Hildebrand, Rae Brager, Michelle K. Demos, Yu-Lung Lau, Luigi D. Notarangelo, Timothy R. Hughes, Catherine M. Biggs, Stuart E. Turvey
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241174.
https://doi.org/10.1084/jem.20241174
Published: 20 May 2025
View articletitled, A multimorphic variant in ThPOK causes an inborn error of immunity with T cell defects and fibrosis
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Includes: Supplementary data
Journal Articles

Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma

Stephen C. Mack, Irtisha Singh, Xiuxing Wang, Rachel Hirsch, Quilian Wu, Rosie Villagomez, Jean A. Bernatchez, Zhe Zhu, Ryan C. Gimple, Leo J.Y. Kim, Andrew Morton, Sisi Lai, Zhixin Qiu, Briana C. Prager, Kelsey C. Bertrand, Clarence Mah, Wenchao Zhou, Christine Lee, Gene H. Barnett, Michael A. Vogelbaum, Andrew E. Sloan, Lukas Chavez, Shideng Bao, Peter C. Scacheri, Jair L. Siqueira-Neto, Charles Y. Lin, Jeremy N. Rich
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e2019019605052025C.
https://doi.org/10.1084/jem.2019019605052025C
Published: 20 May 2025
View articletitled, Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma
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Journal Articles

Defining molecular circuits of CD8+ T cell responses in tissues during latent viral infection

Endi K. Santosa, Jennifer M. Zhang, John C. Sauter, Mariah E. Lee, Brandon D. Ng, Sigrun V. Stulz, Meril Takizawa, Simon Grassmann, Orr-El Weizman, Nicholas M. Adams, Ronan Chaligné, Annette Oxenius, Georg Gasteiger, Colleen M. Lau, Joseph C. Sun
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20242078.
https://doi.org/10.1084/jem.20242078
Published: 19 May 2025
View articletitled, Defining molecular circuits of CD8+ T cell responses in tissues during latent viral infection
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Includes: Supplementary data
Journal Articles

A pathological missense mutation in the deubiquitinase USP5 leads to insensitivity to pain

Flavia T.T. Antunes, Maria A. Gandini, Agustin Garcia-Caballero, Sun Huang, Md Yousof Ali, Eder Gambeta, Ivana A. Souza, Erika K. Harding, Laurent Ferron, Asbjorg Stray-Pedersen, Vinicius M. Gadotti, Gerald W. Zamponi
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241877.
https://doi.org/10.1084/jem.20241877
Published: 16 May 2025
View articletitled, A pathological missense mutation in the deubiquitinase USP5 leads to insensitivity to pain
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Includes: Supplementary data
Journal Articles

“What’s in a name?” Clarifying the identity of RORγt+ antigen-presenting cells

Feiya Ou, Kenneth M. Murphy
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20250760.
https://doi.org/10.1084/jem.20250760
Published: 15 May 2025
View articletitled, “What’s in a name?” Clarifying the identity of RORγt+ antigen-presenting cells
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Journal Articles

Laura Mackay: Don't be afraid to engage

Lucie Van Emmenis
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20250876.
https://doi.org/10.1084/jem.20250876
Published: 13 May 2025
View articletitled, Laura Mackay: Don't be afraid to engage
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Journal Articles

DNGR-1 regulates proliferation and migration of bone marrow dendritic cell progenitors

Ana Cardoso, Michael D. Buck, Bruno Frederico, Probir Chakravarty, Oliver Schulz, Kok Haw Jonathan Lim, Cécile Piot, Mariana Pereira da Costa, Evangelos Giampazolias, Francesca Gasparrini, Neil Rogers, Caetano Reis e Sousa
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241813.
https://doi.org/10.1084/jem.20241813
Published: 13 May 2025
View articletitled, DNGR-1 regulates proliferation and migration of bone marrow dendritic cell progenitors
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Includes: Supplementary data
Journal Articles

BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells

Jing Xu, Zeran Jia, Xiaocui Zhao, Lixia Wang, Gang Jin, Zhuoyang Li, Na Yin, Yinqing Li, Min Peng
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241133.
https://doi.org/10.1084/jem.20241133
Published: 06 May 2025
View articletitled, BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells
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Includes: Supplementary data
Journal Articles

Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon

Åsa Johansson, Mahadevan Venkita Subramani, Bahtiyar Yilmaz, Elisabeth E.L. Nyström, Elena Layunta, Liisa Arike, Felix Sommer, Philip Rosenstiel, Lars Vereecke, Louise Mannerås-Holm, Andy Wullaert, Thaher Pelaseyed, Malin E.V. Johansson, George M.H. Birchenough
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241591.
https://doi.org/10.1084/jem.20241591
Published: 05 May 2025
View articletitled, Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon
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Journal Articles

Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency

Riccardo Castagnoli, Francesca Pala, Poorani Subramanian, Cihan Oguz, Benjamin Schwarz, Ai Ing Lim, Andrew S. Burns, Elena Fontana, Marita Bosticardo, Cristina Corsino, Angelina Angelova, Ottavia M. Delmonte, Heather Kenney, Deanna Riley, Grace Smith, Lisa Ott de Bruin, Vasileios Oikonomou, Lucas Dos Santos Dias, Danielle Fink, Eric Bohrnsen, Cole D. Kimzey, Gian Luigi Marseglia, Guisela Alva-Lozada, Jenna R.E. Bergerson, Ana Brett, Karlla W. Brigatti, Dimana Dimitrova, Cullen M. Dutmer, Alexandra F. Freeman, Hanadys Ale, Steven M. Holland, Francesco Licciardi, Srdjan Pasic, Laura E. Poskitt, David E. Potts, Joseph F. Dasso, Svetlana O. Sharapova, Kevin A. Strauss, Brant R. Ward, Melis Yilmaz, Douglas B. Kuhns, Michail S. Lionakis, Stephen R. Daley, Heidi H. Kong, Julia A. Segre, Anna Villa, Stefania Pittaluga, Jolan E. Walter, Ivan Vujkovic-Cvijin, Yasmine Belkaid, Luigi D. Notarangelo
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241993.
https://doi.org/10.1084/jem.20241993
Published: 02 May 2025
View articletitled, Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency
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Journal Articles

Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination

Michael T. Conlon, Jessica Y. Huang, Michael Y. Gerner
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241311.
https://doi.org/10.1084/jem.20241311
Published: 30 April 2025
View articletitled, Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination
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Includes: Supplementary data
Journal Articles

Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα

Artur Stoljar, Maksym Zarodniuk, Rudolf Bichele, Elise Helene Armulik, Uku Haljasorg, Romain Humeau, Marine Besnard, Liis Haljasmägi, Liina Tserel, Merili Peltser, Ahto Salumets, Eliisa Kekäläinen, Kai Kisand, Carole Guillonneau, Martti Laan, Pärt Peterson
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241403.
https://doi.org/10.1084/jem.20241403
Published: 30 April 2025
View articletitled, Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα
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Includes: Supplementary data
Journal Articles

RORγt eTACs mediate oral tolerance and Treg induction

Im-Hong Sun, Anita E. Qualls, Han S. Yin, Jiaxi Wang, Matthew P. Arvedson, Joe Germino, Nolan K. Horner, Sheng Zhong, Juan Du, Martin Valdearcos, Vasilis Ntranos, Richard M. Locksley, Roberto R. Ricardo-Gonzalez, James M. Gardner
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20250573.
https://doi.org/10.1084/jem.20250573
Published: 29 April 2025
View articletitled, RORγt eTACs mediate oral tolerance and Treg induction
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Includes: Supplementary data
Journal Articles

Sympathetic axonogenesis promotes adenoid cystic carcinoma progression

Chun-Hao Chen, Boris Reva, Nora Katabi, Avishai Wizel, Hongbo Xu, Alan L. Ho, Luc G.T. Morris, Richard L. Bakst, Anuraag S. Parikh, Yotam Drier, Sylvie Deborde, Richard J. Wong
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20242250.
https://doi.org/10.1084/jem.20242250
Published: 24 April 2025
View articletitled, Sympathetic axonogenesis promotes adenoid cystic carcinoma progression
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Includes: Supplementary data
Journal Articles

Vaccination against influenza viruses annually: Renewing or narrowing the protective shield?

Hanover C. Matz, Ali H. Ellebedy
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241283.
https://doi.org/10.1084/jem.20241283
Published: 24 April 2025
View articletitled, Vaccination against influenza viruses annually: Renewing or narrowing the protective shield?
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Journal Articles

Microglia and CD8+ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15

Aleksej Frolov, Hao Huang, Dagmar Schütz, Maren Köhne, Nelli Blank-Stein, Collins Osei-Sarpong, Maren Büttner, Tarek Elmzzahi, Mukhran Khundadze, Marina Zahid, Michael Reuter, Matthias Becker, Elena De Domenico, Lorenzo Bonaguro, Axel Kallies, Helen Morrison, Christian A. Hübner, Kristian Händler, Ralf Stumm, Elvira Mass, Marc D. Beyer
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20232357.
https://doi.org/10.1084/jem.20232357
Published: 23 April 2025
View articletitled, Microglia and CD8+ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15
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Includes: Supplementary data
Journal Articles

Factor XII–driven coagulation traps bacterial infections

Katrin F. Nickel, Anne Jämsä, Sandra Konrath, Praveen Papareddy, Lynn M. Butler, Evi X. Stavrou, Maike Frye, Mathias Gelderblom, Bernhard Nieswandt, Sven Hammerschmidt, Heiko Herwald, Thomas Renné
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20250049.
https://doi.org/10.1084/jem.20250049
Published: 22 April 2025
View articletitled, Factor XII–driven coagulation traps bacterial infections
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Includes: Supplementary data